"Detection of PIGF protein in neonatal rat cardiomyocytes"

dc.contributor.authorSchweizer, Marin
dc.contributor.authorBohman, Kyle
dc.contributor.authorMittelstedter, Carrie
dc.contributor.authorColton, Benjamin
dc.contributor.authorTorry, Ronald J.
dc.contributor.authorTorry, Donald S.
dc.date.accessioned2005-07-05T14:00:44Z
dc.date.available2005-07-05T14:00:44Z
dc.date.issued2005-07-05T14:00:44Z
dc.descriptionMarin Schweizer, Kyle Bohman, Carrie Mittelstedter and Ben Colton are all Drake University students. Ronald J. Torry is Associate Professor of Pharmacology at Drake University. Donald S. Torry is on the faculty at Southern Illinois University School of Medicine.en
dc.description.abstractAngiogenesis, the formation of blood vessels, can provide blood to the heart when its normal arteries are compromised. Angiogenesis is highly dependent on the Vascular Endothelial Growth Factor (VEGF) family. Placental Growth Factor (PlGF) is a member of this family and is crucial for pathological angiogenesis in the adult. PlGF coupled with the more common VEGF could greatly increase angiogenesis in the heart tissue, thus providing oxygen to ischemic heart tissue. Previous research has shown that PlGF mRNA increases with six hours of hypoxia which models ischemia. However, not much is known about PlGF expression on the protein level. We intend to establish that PlGF protein expression will increase in rat cardiomyocytes which have undergone 6, 12 and 24 hours of hypoxia compared to normoxic rat cardiomyocytes. This information will later be used in studies of potential protective treatments using PlGF.en
dc.description.sponsorshipDrake University, College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences.en
dc.format.extent839059 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/2092/277
dc.language.isoen_US
dc.relation.ispartofseriesDUCURS 2005;15
dc.subjectAngiogenesisen
dc.subjectPlacenta Growth Factor (PIGF)en
dc.subjectVascular Endothelial Growth Factor (VEGF)en
dc.subjectIschemic heart diseaseen
dc.title"Detection of PIGF protein in neonatal rat cardiomyocytes"en
dc.typePresentationen
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