Analysis Of Candidate Genes That Suppress Chromosome Loss In Saccharomyces Cerevisiae Mutants With Defects In Chromosome Transmission

dc.contributor.authorAdjei, Naomi
dc.contributor.authorEllis, Alyssa
dc.contributor.authorFeigenbutz, Lanie
dc.contributor.authorGwinn, Traci
dc.contributor.authorKolnik, Jim
dc.contributor.authorMiller, Lindsey
dc.contributor.authorPatel, Neel
dc.contributor.authorPeterson, Kevin
dc.contributor.authorRichardson, Alex
dc.contributor.authorSetsodi, Christine
dc.contributor.authorMichaels, Whitney
dc.date.accessioned2011-04-15T18:49:46Z
dc.date.available2011-04-15T18:49:46Z
dc.date.issued2011-04-15T18:49:46Z
dc.descriptionMentor: Heidi Sleisteren_US
dc.description.abstractErrors in the eukaryotic cell cycle and processes that maintain genome stability can result in abnormal chromosome number and structure (e.g., in humans- Down Syndrome, cancer). The common baker’s yeast S. cerevisiae is a great model system for the analysis of chromosome transmission as yeast artificial chromosomes (YACs) can be lost or rearranged without harming the cell. In an effort to identify proteins important for chromosome transmission, yeast mutants that display increased loss of a YAC during cell division were generated. Suppressor analysis resulted in the isolation of both single and high copy yeast genomic plasmids that improve the chromosome loss defect in these mutants. Subsequent analysis revealed multiple candidate genes present within the suppressor plasmids. Each gene is being individually cloned and assayed for suppression of chromosome loss.en_US
dc.description.sponsorshipDrake University, College of Arts & Sciences, Department of Biologyen_US
dc.identifier.urihttp://hdl.handle.net/2092/1547
dc.language.isoen_USen_US
dc.relation.ispartofseriesDUCURS 2011;2
dc.subjectSaccharomyces cerevisiaeen_US
dc.subjectChromosomesen_US
dc.subjectGenes--Analysisen_US
dc.titleAnalysis Of Candidate Genes That Suppress Chromosome Loss In Saccharomyces Cerevisiae Mutants With Defects In Chromosome Transmissionen_US
dc.typePresentationen_US
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