Molecular Analysis of the Effects of Resveratrol and Genistein on Signal Transduction in Cancer Cells
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Authors
Hornick, Madeleine
Kang, Yutong
Issue Date
2011-04-20T19:17:54Z
Type
Presentation
Language
en_US
Keywords
Resveratrol--Analysis , Genistein--Analysis , Cancer cells
Alternative Title
Abstract
The overall objective of our research project is to study the effects of Genistein and Resveratrol on
cancer cell proliferation. Resveratrol, a stilbene found in high quantities in red grape skin, and Genistein,
an isoprenoid found in soy, are both available in supplement form and have exhibited antioxidative
properties. Recent studies have suggested Genistein and Resveratrol may inhibit growth of
certain types of cancer cells in culture, and that diets with higher levels of these two compounds have
shown lower incidence of certain types of cancers and inflammatory disorders. However, the precise
mechanisms of their antiproliferative effects only on certain types of cancer cells remain poorly defined.
Our project focuses on studying the anti-proliferative effects of Resveratrol and Genistein on
signal transduction pathways in two human breast cancer cell lines and one human ovarian cancer cell
line in culture. Specifically, this poster presents results examining the role of phosphorylation of two
signal transduction enzymes, PDK1 and Akt1.
Description
Mentors: Dr. Deepa Rao and Dr. Pramod Mahajan