An X Chromatin Survey at Woodward State Hospital and Training School, an Institution for the Mentally Retarded
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Authors
Lyman, Janet K.
Issue Date
1975-07
Type
Thesis
Language
en_US
Keywords
Psychiatric hospitals--Surveys , People with mental disabilities--Institutional care--Surveys , X chromosome--Abnormalities--Surveys , X-linked mental retardation--Surveys
Alternative Title
Abstract
The problem. The majority of the Woodward State
hospital and training school population was surveyed to locate and identify residents with X chromatin abnormalities.
Procedure. Buccal smears were taken from each
resident. The smears were stained with cresyl fast violet and examined under 1250X magnification. The number of Barr bodies per 100 cells was noted and recorded for each resident
sampled.
Findings. One male out of a total male population of 278 surveyed was found to be chromatin positive, a frequency of 0.4%. Since four cell lines were observed in the buccal smear analysis, he was classified as a mosaic for his X
chromosome makeup. Analysis of a population of 193 females showed one female with an abnormal X chromatin count, a 0.5% frequency. Since this female's buccal smear count was just slightly lower than that considered normal, she was classified as a mosaic of the type 45,X/46,XX.
Conclusions. The frequency of X chromatin males at
WSHTS was generally lower than the frequencies found in surveys of residents in other institutions for the mentally retarded. The frequency of females with abnormal X chromatin
counts at WSHTS was in close agreement with that found in other similar surveys.
Recommendations. The residents found in the WSHTS
survey with abnormal X chromatin counts should be
investigated by karyotype analysis to determine the specific features of the abnormality.
Description
33 leaves. Advisor: Michael E. Myszewski
Citation
Publisher
Drake University