The Immune Status of Two Bloom's Syndrome Siblings
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Authors
Bray, Janice J.
Issue Date
1985-12
Type
Thesis
Language
en_US
Keywords
Brothers and sisters--Genetic aspects , Brothers and sisters--Immune response
Alternative Title
Abstract
The problem. Two sibling brothers have been previously diagnosed as Bloom's Syndrome (BS). Due to lack of demonstrable increased sister chromatid exchange (SCE) in their blood cells and fibroblasts, diagnosis of BS is in question.
Procedure. This study examined the immune reactions of these siblings with such tests of immune function as: T- and B-cells, T-cell subsets, chemotaxis, nitroblue tetrazolium (NBT), mitogen stimulation and mixed lymphocyte culture (MLC).
Findings. Results are compared with those of other
known BS subjects. Analysis of our patients' immune systems seems to agree with findings of previous studies.
Conclusion. While there is a correlation of
immunological and clinical data, genetically there are none of the expected abnormalities. This study has not ruled out the possibility of a misdiagnosis of BS.
Description
32 leaves. Advisor: Dean Hoganson
Citation
Publisher
Drake University