The Effects of Leucogenenol On Benzene Induced Bone Marrow Suppression In Rabbits

Abstract

The problem. These experiments were to determine the extent of leucocytosis and antibody production, stimulated by leucogenenol, in an animal whose white blood cells have been reduced by the action of benzene. Procedure. The white blood cell counts of rabbits were depressed to 1500 ± 500 cells per cubic millimeter by the action of benzene. At this time the animal, depending upon the grouping, was either given an injection of leucogenenol (2.0 or 0.2 ug) or allowed to recover on its own. Five groups of rabbits were maintained: Group 1, Control animals; Group 2, Benzene only; Group 3, Leucogenenol only; Group 4, Benzene and 0.2 ug of Leucogenenol; Group 5, Benzene and 2.0 ug of Leucogenenol. Findings. The variations of the rabbits blood profile did not provide significant results. The data seemed to indicate possibilities rather than firm conclusions. The differences between the control group and the experimental group were only slight and not clear or directional. Conclusion. The findings, although slight, indicate that leucogenenol does stimulate leucocytosis and antibody formation. Recommendations. With the use of an agent such as benzene, the effects of leucogenenol can be easily observed. The rabbit as the experimental animal should be changed to one more suitable.