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dc.contributor.authorChamney, Carissa
dc.contributor.authorGarrigan, Ethan
dc.descriptionMentor: Kimberly Hueyen_US
dc.description.abstractSpinal cord injury (SCI) results in loss of muscle function due to the rapid breakdown of muscle contractile proteins and high incidence of inflammation that directly hinder rehabilitation. Glutamine is an amino acid that plays a critical role in muscle integrity and in reducing inflammation, however, impaired glutamine synthesis occurs under stressful conditions. Glutamine supplementation can improve clinical outcomes from acute infection to sepsis, but its effects on skeletal muscle function in the early stages after a SCI are unknown. Based on glutamine’s benefits and clinical applicability these experiments tested the hypothesis that glutamine treatment can preserve muscle mass, strength, and fatigue resistance in a mouse model of SCI. Changes in muscle mass, maximal isometric force, and fatigability will be measured 7 days after sham or spinal cord transection (ST) surgery in mice receiving either placebo or glutamine (n=3-5/group). ST significantly reduced gastrocnemius mass independent of saline or glutamine treatment. Maximal isometric force normalized to body or muscle mass was not different among groups. Fatigue resistance was reduced with ST + saline, however, glutamine supplementation prevented the loss of fatigue resistance (38±9 vs. 57±5% of max force, respectively). Preliminary results suggest that 7 days after a SCI significant reductions in muscle fatigue resistance can be reversed by glutamine supplementation. Additional studies can continue to establish the protective effects of glutamine on muscle endurance with SCI, underscoring the importance of glutamine as a therapeutic intervention to accelerate the recovery of muscle function after a SCI.en_US
dc.description.sponsorshipDrake University, College of Pharmacy & Health Sciencesen_US
dc.relation.ispartofseriesDUCURS 2011;41
dc.subjectMuscle proteinsen_US
dc.subjectSpinal corden_US
dc.subjectMice as laboratory animalsen_US
dc.titleEffects of Glutamine Supplementation on Muscle Function in a Mouse Model of Spinal Cord Injuryen_US

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    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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