Now showing items 1-3 of 3

    • Learning and memory impairments in mice lacking the M2 subtype of muscarinic receptor 

      Bainbridge, Natalie K.; Koselke, Lisa R.; Jeon, Jongrye; Wess, Jurgen; Crawley, Jacqueline N.; Wrenn, Craige C. (2007-05-31)
      The neurotransmitter acetylcholine is an important modulator of cognitive functions such as learning, memory, and attention. These functions of acetylcholine are mediated by its binding to five distinct subtypes of muscarinic ...
    • Modeling Alzheimer’s disease in mice by selectively lesioning the cholinergic basal forebrain 

      Arter, Natalie; Wrenn, Craige C. (2007-06-01)
      One pathological feature of Alzheimer’s disease (AD) is the degeneration of the cholinergic basal forebrain (CBF). The importance of this degeneration in AD is suggested by the observation that the degree of CBF degeneration ...
    • Molecular Analysis of Isoflavonoid Genotoxicity 

      Walker, Greg; Verlinden, Nathan; Wrenn, Craige C. (2009-06-24)
      Overall objective of our research project is to analyze, at the molecular level, the genotoxic effects of genistein, the main isoflavonoid in soybeans. Due to their anti-oxidative properties, soy isoflavonoids have received ...