An Immunologic Investigation of Bisalbuminemia : A Genetically Transmitted Serum Protein Anomaly
Vertuno, Lee Stuart
MetadataShow full item record
The problem. Bisalbuminemia was investigated in an Iowa family by testing for hematological and immunologic abnormalities to determine associations between bisalbuminemia and connective tissue (collagen) and/or autoimmune diseases. Physiochemical properties of the anomalous albumin fraction were compared to normal serum albumin. Procedure. Cellulose acetate electrophoresis was used to determine the genotypes from which was established the genetic pedigree of the bisalbumin trait. Sera of family members was screened using the following tests: Complete blood count; sedimentation rate; hematocrit; antistreptolysin 0 titer; rheumatoid factor; LE preparation; VDRL; C-reactive protein and fluorescent anti-nuclear antibody analysis. Physiochemical characterization of the anomalous albumin fraction included an agar-gel diffusion study and measurement of the relative binding ability of normal and abnornal albumins using I125-thyroxine. Findings. Bisalbuminemia was found in seven of fourteen members of an Iowa family and was presumed to have been present in one deceased member of the family. The anomaly, transmitted as an autosomal codominant, was observed in the heterozygous state. The anomalous albumin fraction, albumin B, replaces one-half of the normal serum albumin and was found to be an albumin by agar-gel diffusion. Tests commonly associated with connective tissue and autoimmune diseases failed to show a relationship between the disease groups and bisalbuminemia. Addition of I125-thyroxine to bisalbumin sera resulted in excess thyroxine binding to albumin B with greater affinity than to normal albumin. Conclusions. The anomalous albumin B is assumed to be the result of a mutation of a gene responsible for the synthesis of normal serum albumin. The bisalbuminemia analyzed in this family study does not appear to be associated with the connective tissue and/or autoimmune diseases or any marked clinical abnormalities.
29 leaves. Advisor: Michael Myszewski
Showing items related by title, author, creator and subject.
Clemens, Evelyn L. Schnoor (Drake University, 1992-05)The problem: Current accepted therapeutic modality in dietary management for individuals with chronic obstructiv e pulmonary disease(COPD)includes 40-50% of the caloric intake to come from fat sources. According to current ...
"Protective effect of Placenta Growth Factor (PIGF) against hypoxia-reoxgyenation and serum-deprivation induced apoptosis in neonatal rat cardiomyocytes" Bohman, Kyle; Schweizer, Marin; Berendt, Bob; Torry, Ronald J.; Torry, Donald S. (2005-07-05)Placenta growth factor (PlGF) is known to induce angiogenesis and protect placental trophoblast from apoptosis. We have shown that PlGF mRNA expression is increased in hypoxic human myocardium and in rat neonatal ...
Effects of Marek's Disease Herpesvirus and Turkey Herpesvirus Upon Immunity to Eimeria Acervulina in Young Chickens Herr, Marvin Leroy (Drake University, 1975-01)The problem. Concurrent infections with Marek's disease (MD) and coccidiosis in chicken flocks have perplexed investigators for years. Infection with MD herpesvirus has been shown to inhibit immunity of chicks to ...