Protein-Protein Interactions in Drosophila Germ Cell Development

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Show simple item record Dzogbeta, Seli Fisher, Molly Boyer, Michael 2009-06-24T18:33:47Z 2009-06-24T18:33:47Z 2009-06-24T18:33:47Z
dc.description Advisor: Martin Schmidt of Des Moines University en_US
dc.description.abstract During germ cell formation in Drosophila embryos, cells migrate from their site of origin to the site of organ formation. In particular, germ cells need to migrate long distances from their site of origin to the site where ovaries and testicles develop. It was found that the this cell migration is guided by a chemical signaling pathway. Cells which digress from the migration route are destroyed by apoptosis. Dr. Coffman's group at Iowa State University has identified mutations that impair the destruction of cells that have strayed from their migration path. One of these mutations affects the function of a G-protein coupled receptor, Trel. In this study we look at physical interactions of the Trel protein with ten candidate proteins. We have identified interactions between the G-protein coupled receptor Trel and two, possibly three, candidate proteins. These candidates are members of a protein phosphatase family that have previously been implicated in germ cell migration, which makes our result particularly valuable. Adding to the picture is the fact that the phenotypes of mutations in the corresponding genes closely resemble trel mutant phenotypes. All of the above results indicate that these proteins function in the same pathway. en_US
dc.description.sponsorship Drake University, College of Arts and Sciences, Department of Biology, Biochemistry, Cell and Molecular Biology Department ; Biochemistry and Nutrition, Des Moines University en_US
dc.language.iso en_US en_US
dc.relation.ispartofseries DUCURS 2009;40
dc.subject Protein-protein interactions en_US
dc.subject Drosophilia en_US
dc.subject Germ cells--Development en_US
dc.title Protein-Protein Interactions in Drosophila Germ Cell Development en_US
dc.type Presentation en_US

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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