The Effect of Aversive Early Experience on the Behavioral and Biological Fear Response in Rats
MetadataShow full item record
The effects of both positive and negative early life experiences on subsequent emotional reactivity are a major focus in current research on the etiology of neuropsychiatric disorders. Specifically, traumatic events, particularly when combined with genetic vulnerability, may exert a profound influence on the future psychological and biological development of an organism. In this study our lab examined the effects of a traumatic event early in life, maternal separation, on the future biobehavioral reactivity in animals with (borderline hypertensive rats) and without (Sprague-Dawley) a genetic predisposition for cardiovascular and emotional reactivity. Subjects were separated from the litter for two hours from post-natal days 1 through 14. Beginning at 6 weeks of age, anxiety-like behavior and locomotor activity was tested by elevated plus maze and open field, respectively. One day following implantation of an arterial catheter, fear conditioning was used to produce an aversive emotional event (lO pairings an environmental cue (tone) followed by a brief lmA footshock). 24 hours later, emotional (e.g., freezing, vocalizations) and biological (e.g., blood pressure, corticosterone) responses were assessed in all subjects in response to re-exposure to the context (original context) and cue (altered context + tone). Results could provide an explanation for some of the differences between those susceptible to neuropsychiatric disorders like PTSD and those who are resistant. Results may also be used to expand upon the emerging body of research concerning the link between cardiovascular disease and PTSD.
Showing items related by title, author, creator and subject.
A Comparison of Interactions Between Mothers With Their Normal Children and Mothers With Their Retarded Children Kopp, John R. (Drake University, 1976-12)The problem. To observe and compare interactions of mothers and their normal children with mothers and their retarded children including attempts to modify behavior and the comparative success of those attempts. Procedure. ...
Effects of Audio Cueing on Teacher Praise and Subsequent Effects on Children's Rule Violations in a Day Care Berty, Peter Tamas (Drake University, 1977-06)The problems. The experimental problems were to demonstrate the effectiveness of an audio cueing procedure in manipulating teacher praise and to assess any subsequent changes in students' violations of classroom rules in ...
The Effects of Feedback on the Performance of Paraprofessional Behavior Modifiers and Their Retarded-Trainees German, Mark (Drake University, 1975-07)The problem. To determine whether the behavior modification skills of hospital attendants are improvable by program respecifications, delayed graphic feedback, or by immediate verbal feedback. To also determine if these ...