The Use of Dexmedetomidine for Sedation in the Pediatric Intensive Care Unit
MetadataShow full item record
SubjectPediatric intensive care; Analgesia--Children; Anesthesia--Children; Respiratory insufficiency
Dexmedetomidine is a centrally acting alpha2-adrenergic agonist that provides sedation with minimal respiratory depression. The medication's targeted activation of alpha2-receptors mediates its sedative, anxiolytic, and analgesic effects. Although dexmedetomidine is approved only for sedation in adults, it is currently being used off-label as an adjunctive agent in pediatric patients for sedation and analgesia in the critical care unit and for sedation during non-invasive procedures in radiology. Despite the lack of large randomized controlled trials, available literature and case studies suggest dexmedetomidine may be an effective alternative or adjunctive sedative in pediatric patients. The purpose of this study is to evaluate the use of dexmedetomidine in the Pediatric Intensive Care Unit (PICU) at Blank Children's Hospital (BCH) by assessing safety, efficacy, dosing, and duration of dexmedetomidine courses in mechanically ventilated infants and children. The study will also assess length of stay, time on the ventilator, extubation while receiving dexmedetomidine infusion, and necessity for use of other sedative and narcotic infusions. These objectives will be assessed through retrospective chart review of all patients who received dexmedetomidine while in the PICU between March 2007 and January 2009. Analysis will include descriptive statistics on the data obtained. The results will add to the small volume of existing evidence regarding dexmedetomidine's use in the pediatric population.
Advisor: Geoff Wall of Iowa Methodist Medical Center
Showing items related by title, author, creator and subject.
Meeks, Reylon A. (Drake University, 1990)This study investigated the state anxiety level of the parent whose child had been admitted to the Pediatric Intensive Care Unit (PICU) with restricted visiting hours and the state anxiety level of the parent whose child ...
Ionization Of The Hydrogen Molecular Ion By Ultrashort Intense Elliptically Polarized Laser Radiation DuToit, Ryan (2013-04-17)We report results for the single- and multi-photon ionization of the H2 + ion irradiated by ultrashort elliptically polarized laser pulses with central photon energies from the ionization threshold up to 300 eV. Using the ...