Molecular Analysis of Isoflavonoid Genotoxicity

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Show simple item record Walker, Greg Verlinden, Nathan Wrenn, Craige C. 2009-06-24T13:34:47Z 2009-06-24T13:34:47Z 2009-06-24T13:34:47Z
dc.description Advisor: Pramod Mahanjan en_US
dc.description.abstract Overall objective of our research project is to analyze, at the molecular level, the genotoxic effects of genistein, the main isoflavonoid in soybeans. Due to their anti-oxidative properties, soy isoflavonoids have received considerable attention as health food supplements. Recent studies have also documented a variety of other biological effects of isoflavonoids including anticancer activity. Some of these effects are due to structural similarity of genistein with steroid hormones, and some effects are thought to be due to the ability of genistein to interfere with cellular pathways involved in drug metabolism or cell cycle progression. However, it is unclear if the observed toxicity of genistein toward some types of cancer cells is specific and limited only to the cancer cells. Moreover, reasons for the genotoxic effects of genistein remain unexplained. We hypothesize that the genotoxic effects of isoflavonoids are mediated via damage to cellular DNA and subsequent modulation of the DNA damage repair pathways of the host cells. Fully understanding molecular mechanisms of the genotoxic effects of genistein will significantly improve utility of genistein and other isoflavones as pharmaceutical/neutraceutical compounds. Therefore, we are evaluating the genotoxic effects of genistein in rats as an animal model using Poly-ADP-ribose polymerase as a marker of DNA damage. This poster outlines the rationale, experimental approaches and preliminary results of our studies. en_US
dc.description.sponsorship Drake University, College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences en_US
dc.language.iso en_US en_US
dc.relation.ispartofseries DUCURS 2009;23
dc.subject Genetic toxicology en_US
dc.subject Dietary supplements en_US
dc.subject DNA en_US
dc.subject NAD-ADP-ribosyltransferase en_US
dc.subject Rats as laboratory animals en_US
dc.title Molecular Analysis of Isoflavonoid Genotoxicity en_US
dc.type Presentation en_US

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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