The Effects of Leucogenenol On Benzene Induced Bone Marrow Suppression In Rabbits

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dc.contributor.author Talluto, Joseph Francis
dc.date.accessioned 2009-06-17T19:27:43Z
dc.date.available 2009-06-17T19:27:43Z
dc.date.issued 1976-04
dc.identifier.other 1976 .T147
dc.identifier.uri http://hdl.handle.net/2092/935
dc.description 36 leaves. Advisor: Dr. Rodney A. Rogers en_US
dc.description.abstract The problem. These experiments were to determine the extent of leucocytosis and antibody production, stimulated by leucogenenol, in an animal whose white blood cells have been reduced by the action of benzene. Procedure. The white blood cell counts of rabbits were depressed to 1500 ± 500 cells per cubic millimeter by the action of benzene. At this time the animal, depending upon the grouping, was either given an injection of leucogenenol (2.0 or 0.2 ug) or allowed to recover on its own. Five groups of rabbits were maintained: Group 1, Control animals; Group 2, Benzene only; Group 3, Leucogenenol only; Group 4, Benzene and 0.2 ug of Leucogenenol; Group 5, Benzene and 2.0 ug of Leucogenenol. Findings. The variations of the rabbits blood profile did not provide significant results. The data seemed to indicate possibilities rather than firm conclusions. The differences between the control group and the experimental group were only slight and not clear or directional. Conclusion. The findings, although slight, indicate that leucogenenol does stimulate leucocytosis and antibody formation. Recommendations. With the use of an agent such as benzene, the effects of leucogenenol can be easily observed. The rabbit as the experimental animal should be changed to one more suitable. en_US
dc.language.iso en_US en_US
dc.publisher Drake University en_US
dc.relation.ispartofseries Drake University, School of Graduate Studies;1976
dc.subject Leucocytosis en_US
dc.subject Rabbits as laboratory animals en_US
dc.subject Benzene en_US
dc.subject Bone marrow en_US
dc.title The Effects of Leucogenenol On Benzene Induced Bone Marrow Suppression In Rabbits en_US
dc.type Thesis en_US


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