Investigations into the Actions of Vasopressin Histamine, Isoproterenol, Phentolamine, Phenylephrine, and Propronalol on Flow Through Perfused Rat Livers

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Hepplewhite, David Wilson
dc.date.accessioned 2008-09-17T19:19:12Z
dc.date.available 2008-09-17T19:19:12Z
dc.date.issued 1978-05
dc.identifier.other 1978 .H612
dc.identifier.uri http://hdl.handle.net/2092/776
dc.description 197 leaves. Advisor: Harold D. Swanson en
dc.description.abstract The problem. The experiments were intended to elucidate any intrahepatic actions of the drugs employed as presinusoidal or postsinusoidal and to identify any antagonism of the drugs to others. Procedure. Livers were excised and perfused at a constant rate through the portal vein with different drugs and at different concentrations. Absolute pressure and change of weight were recorded continuously. Findings. No consistent effects were found with the methods employed. Several factors were not important to this lack of action and several others appear possibly important. Recommendations. Further investigation should be undertaken to identify a procedure that will show actions for those drugs and oxytocin. Once a procedure is identified, any actions of the drugs should be characterized as pre- or postsinusoidal, and the adrenergic agonists, histamine, and vasopressin should be tested for antagonism of each other. Dog livers as well as rat livers and healthy as well as cirrhotic livers should be tested because they would provide important data to compare with other research. en
dc.format.extent 14454252 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.publisher Drake University en
dc.relation.ispartofseries Drake University, School of Graduate Studies;1978
dc.subject Rats as Laboratory Animals en
dc.subject Isoproterenol--Analysis en
dc.subject Phentolamine--Analysis en
dc.title Investigations into the Actions of Vasopressin Histamine, Isoproterenol, Phentolamine, Phenylephrine, and Propronalol on Flow Through Perfused Rat Livers en
dc.type Thesis en


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account