The Immune Status of Two Bloom's Syndrome Siblings

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Show simple item record Bray, Janice J. 2007-08-03T17:39:24Z 2007-08-03T17:39:24Z 1985-12
dc.identifier.other 1985 .B739
dc.description 32 leaves. Advisor: Dean Hoganson en
dc.description.abstract The problem. Two sibling brothers have been previously diagnosed as Bloom's Syndrome (BS). Due to lack of demonstrable increased sister chromatid exchange (SCE) in their blood cells and fibroblasts, diagnosis of BS is in question. Procedure. This study examined the immune reactions of these siblings with such tests of immune function as: T- and B-cells, T-cell subsets, chemotaxis, nitroblue tetrazolium (NBT), mitogen stimulation and mixed lymphocyte culture (MLC). Findings. Results are compared with those of other known BS subjects. Analysis of our patients' immune systems seems to agree with findings of previous studies. Conclusion. While there is a correlation of immunological and clinical data, genetically there are none of the expected abnormalities. This study has not ruled out the possibility of a misdiagnosis of BS. en
dc.format.extent 1937045 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.publisher Drake University en
dc.relation.ispartofseries Drake University, School of Graduate Studies;1985
dc.subject Brothers and sisters--Genetic aspects en
dc.subject Brothers and sisters--Immune response en
dc.title The Immune Status of Two Bloom's Syndrome Siblings en
dc.type Thesis en

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