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dc.contributor.authorBray, Janice J.
dc.date.accessioned2007-08-03T17:39:24Z
dc.date.available2007-08-03T17:39:24Z
dc.date.issued1985-12
dc.identifier.other1985 .B739
dc.identifier.urihttp://hdl.handle.net/2092/611
dc.description32 leaves. Advisor: Dean Hogansonen
dc.description.abstractThe problem. Two sibling brothers have been previously diagnosed as Bloom's Syndrome (BS). Due to lack of demonstrable increased sister chromatid exchange (SCE) in their blood cells and fibroblasts, diagnosis of BS is in question. Procedure. This study examined the immune reactions of these siblings with such tests of immune function as: T- and B-cells, T-cell subsets, chemotaxis, nitroblue tetrazolium (NBT), mitogen stimulation and mixed lymphocyte culture (MLC). Findings. Results are compared with those of other known BS subjects. Analysis of our patients' immune systems seems to agree with findings of previous studies. Conclusion. While there is a correlation of immunological and clinical data, genetically there are none of the expected abnormalities. This study has not ruled out the possibility of a misdiagnosis of BS.en
dc.format.extent1937045 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherDrake Universityen
dc.relation.ispartofseriesDrake University, School of Graduate Studies;1985
dc.subjectBrothers and sisters--Genetic aspectsen
dc.subjectBrothers and sisters--Immune responseen
dc.titleThe Immune Status of Two Bloom's Syndrome Siblingsen
dc.typeThesisen


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