Looking for indicators of imminent cardiovascular collapse

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dc.contributor.author Anklam, Ashley
dc.contributor.author Dumke, Breanna
dc.contributor.author Mueller, Dana
dc.contributor.author Verdick, Christopher
dc.contributor.author Woodard, Meredith
dc.contributor.author Hopkins, James
dc.contributor.author Devey, Jennifer
dc.contributor.author Buising, Charisse
dc.contributor.author Henderson, LaRhee
dc.contributor.author Wall, Piper
dc.date.accessioned 2007-05-31T20:51:00Z
dc.date.available 2007-05-31T20:51:00Z
dc.date.issued 2007-05-31T20:51:00Z
dc.identifier.uri http://hdl.handle.net/2092/570
dc.description.abstract Various indicators are used as predictors of lifesaving intervention requirements and mortality risk following severe hemorrhage. We examined hemorrhage and resuscitation data for sensitive and specific indications of imminent cardiovascular collapse. Methods: 8 anesthetized, ventilated dogs were hemorrhaged (H, 90min mean arterial pressure [MAP]=35-40mmHg or MAP<30mmHg>10min or MAP<25mmHg>1min), hypotensively stabilized (S, 120min enalaprilat 0.01mg/kg/hr + hemoglobin based oxygen carrier [HBOC] or 7.8% hypertonic saline dextran 70 [HSD] for MAP=40-45mmHg), resuscitated (60min lactated Ringer’s for MAP=75-80mmHg), monitored (60min no fluids), and euthanized. Results: 2 of 8 died of cardiovascular collapse: 1 of 5 HBOC 117min into S and 1 of 3 HSD 9min into S. No threshold values were found for predicting cardiovascular collapse. Within the 30 minute interval preceding death, trend differences (sharply declining values for heart rate, blood pressure, and end-tidal PCO2) were visible only in the final 10 minutes. Conclusions: Perhaps these visible trends could be useful for guiding the application of high risk interventions to patients who would die if they only received conventional care. The shortness of the pre-death window may limit the usefulness of the observed patterns. en
dc.description.sponsorship Eagles, Iowa Space Grant Consortium en
dc.format.extent 2423982 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2006;26
dc.subject Hemorrhage en
dc.subject Resuscitation en
dc.subject Hypertension en
dc.subject Cardiovascular system -- Physiology en
dc.subject Hemorrhagic shock -- Treatment en
dc.title Looking for indicators of imminent cardiovascular collapse en
dc.type Presentation en


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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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