Analysis of mRNA changes as a function of learning and methamphetamine exposure

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Show simple item record Kostelc, Kate Sleister, Heidi Klipec, William D. 2007-05-31T18:55:44Z 2007-05-31T18:55:44Z 2007-05-31T18:55:44Z
dc.description.abstract Methamphetamine is a powerful, addictive drug that is of great concern in Iowa and the Midwest. Powerful methamphetamine abuse is correlated with depression and learning disabilities (e.g. attention deficit disorder). Although the mechanism of action of methamphetamine in the brain has been well characterized at the cellular and synaptic level, the effects of this drug at the genetic level are not well understood. To analyze the possible effects of methamphetamine on learning, we are using real-time PCR to investigate changes in gene expression (i.e., messenger RNA levels) in rat brains as a function of learning and exposure to methamphetamine. Specifically, we are analyzing relative mRNA levels from genes whose products have been implicated in learning and/or addiction: GABA receptors, dopamine receptors, and glutamate (NMDA) receptors. Comparison of these data sets is expected to reveal potential cellular and molecular mechanisms involved in producing drug-induced learning disabilities. en
dc.format.extent 2421892 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2006;3
dc.subject Drug-induced learning disabilities en
dc.subject Methamphetamine en
dc.subject Methamphetamine -- Physiological effect en
dc.subject Methamphetamine abuse en
dc.subject Messenger RNA en
dc.title Analysis of mRNA changes as a function of learning and methamphetamine exposure en
dc.type Presentation en

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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