Gross tissue appearances following hemorrhage, low-pressure stabilization, and resuscitation

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dc.contributor.author Hatz, Daniel
dc.contributor.author McCarty, Bryan M.
dc.contributor.author Hukee, Luke
dc.contributor.author Olson, Natalie
dc.contributor.author Slycord, Susan
dc.contributor.author Hopkins, James
dc.contributor.author Devey, Jennifer
dc.contributor.author Buising, Charisse
dc.contributor.author Wall, Piper
dc.contributor.author Henderson, LaRhee
dc.date.accessioned 2007-05-31T14:44:35Z
dc.date.available 2007-05-31T14:44:35Z
dc.date.issued 2007-05-31T14:44:35Z
dc.identifier.uri http://hdl.handle.net/2092/554
dc.description.abstract In a severe prolonged hemorrhage and resuscitation protocol, when do gross abnormalities become apparent? Hypothesis: Gross tissue abnormalities will be more obvious in those animals that survive longer. Methods: 8 anesthetized, ventilated dogs were hemorrhaged (H, 90min mean arterial pressure [MAP]=35-40mmHg or MAP<30mmHg>10min or MAP<25mmHg>1min), hypotensively stabilized (S, 120min enalaprilat 0.01mg/kg/hr + hemoglobin based oxygen carrier [HBOC] or 7.8% hypertonic saline dextran 70 [HSD] for MAP=40-45mmHg), resuscitated (60min lactated Ringer’s for MAP=75-80mmHg), monitored (60min no fluids), and euthanized. Every animal was necropsied, and the internal organs were examined for visible abnormalities. Results: There were 2 early non-survivors: 1 of 5 HBOC died 117min into S and 1 of 3 HSD died 9min into S. The rest survived to euthanasia (331min). No damage to the heart was visible in any animal. No lungs looked normal. On cross section, some of the renal cortices were much darker than normal, but this was not restricted to treatment group or non-survivors. Gastric, small and large intestinal mucosae were not normal in any animal, but the 2 early non-survivors were among those with the least abnormal intestines. Conclusions: Grossly visible changes in appearance occurred in most organs. Similar abnormalities in organ appearances (except possibly the intestines) in the 2 non-survivors versus survivors suggest that damage developed during hemorrhage rather than during resuscitation. This suggests that improvements in strategies for resuscitation from severe, prolonged hemorrhage should target repair of already damaged tissues in addition to prevention of additional tissue damage. en
dc.description.sponsorship Eagles, Iowa Space Grant Consortium en
dc.format.extent 2032879 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2006;13
dc.subject Tissue damage en
dc.subject Necropsy en
dc.subject Hemorrhagic shock -- Treatment en
dc.subject Resuscitation en
dc.subject Tissues en
dc.title Gross tissue appearances following hemorrhage, low-pressure stabilization, and resuscitation en
dc.type Presentation en


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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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