Learning and memory impairments in mice lacking the M2 subtype of muscarinic receptor

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dc.contributor.author Bainbridge, Natalie K.
dc.contributor.author Koselke, Lisa R.
dc.contributor.author Jeon, Jongrye
dc.contributor.author Wess, Jurgen
dc.contributor.author Crawley, Jacqueline N.
dc.contributor.author Wrenn, Craige C.
dc.date.accessioned 2007-05-31T14:14:18Z
dc.date.available 2007-05-31T14:14:18Z
dc.date.issued 2007-05-31T14:14:18Z
dc.identifier.uri http://hdl.handle.net/2092/553
dc.description.abstract The neurotransmitter acetylcholine is an important modulator of cognitive functions such as learning, memory, and attention. These functions of acetylcholine are mediated by its binding to five distinct subtypes of muscarinic acetylcholine receptor (M1, M2, M3, M4, M5). It is largely unknown which receptor subtypes mediate which functions of acetylcholine because of the lack of availability of subtype-selective drugs. The present study examined the behavioral functions of the M2 subtype of muscarinic receptor by utilizing mice possessing a null-mutation in the gene for M2 (M2KO mice). Assessments of general health and neurological function found no differences between M2KO and wild-type (WT) mice. In assessments of sensory function, M2KO mice showed increased pain sensitivity relative to WT mice in the tail-flick test and decreased dishabituation to a novel odor in an olfactory habituation-dishabituation test. In tests of learning and memory, M2KO mice were impaired in the acquisition (trials to criterion), but not the retention (72 hr) of a passive avoidance task. M2KO mice were impaired in between-sessions, but not within session habituation, and M2KO mice committed more working memory and reference memory errors in a holeboard test of spatial memory function. M2KO mice showed no impairments in either cued or contextual fear conditioning. In summary, the present behavioral data indicate that the M2 receptor is necessary for normal nociception, olfaction, and cognitive function. en
dc.format.extent 2751117 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2006;14
dc.subject Learning en
dc.subject Memory en
dc.subject Acetylcholine en
dc.subject Acetylcholine -- Receptors en
dc.subject Muscarinic receptors en
dc.subject Neurochemistry en
dc.title Learning and memory impairments in mice lacking the M2 subtype of muscarinic receptor en
dc.type Presentation en

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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