Biobehavioral responses to conditioned fear and restraint stress in borderline hypertensive rats (BHR)

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dc.contributor.author Knoepfler, J.D.
dc.contributor.author Sanders, B.J.
dc.date.accessioned 2007-05-29T16:11:45Z
dc.date.available 2007-05-29T16:11:45Z
dc.date.issued 2007-05-29T16:11:45Z
dc.identifier.uri http://hdl.handle.net/2092/552
dc.description.abstract The purpose of this experiment was to determine the effects of an early environmental manipulation, handling (H), on cardiovascular (CV) reactivity, freezing behavior and corticosterone (CORT) responses to fear conditioning in the BHR, which is genetically susceptible to environmental stressors. H subjects were separated from the nest for 15 mins/day on post-natal days 1-14, while non-handled (NH) controls remained in the home cage. Adult BHR from each group were implanted with a femoral arterial catheter for mean arterial pressure (MAP) recording and blood sampling. Two days later, subjects were exposed to the fear conditioning procedure. Subjects were returned to the chamber the next day for 10 min during which time freezing behavior, CV responses and CORT measurements were taken. H subjects displayed significantly more freezing behavior compared to NH (92%±2.2 vs. 80.7%±5.7, p < .05). Although resting MAP did not differ between groups, H subjects had increased MAP reactivity when returned to the fear conditioning chamber (p < .01). Finally, H subjects had significantly lower CORT levels at the end of the 10 min test period (173±8 ng/ml vs. 217.7±22.2 ng/ml, p < .05). In a separate experiment, H subjects showed reduced CORT levels in response to acute restraint stress. These results indicate that neonatal H produces enhanced biobehavioral responses to fear conditioning in BHR and may suggest a useful model with which to study the interaction of genetics, emotionality, and heart disease. en
dc.description.sponsorship NIH grant HL073894 en
dc.format.extent 64264 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2006;7
dc.subject Hypertension en
dc.subject Stress (Physiology) en
dc.subject Rats -- Physiology en
dc.subject Diseases -- Animal models en
dc.subject Conditioned response en
dc.subject Fear en
dc.title Biobehavioral responses to conditioned fear and restraint stress in borderline hypertensive rats (BHR) en
dc.type Presentation en


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  • DUCURS [193]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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