HPG function in men and women stratified by drug use and HIV status

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dc.contributor.author Frankowicz, Jacek
dc.contributor.author Wisniewski, Amy B.
dc.date.accessioned 2007-05-29T14:11:55Z
dc.date.available 2007-05-29T14:11:55Z
dc.date.issued 2007-05-29T14:11:55Z
dc.identifier.uri http://hdl.handle.net/2092/548
dc.description.abstract Most studies of hypothalamic-pituitary-gonadal (HPG) function and depression in illicit drug users focus only on men or do not consider the impact of HIV infection along with drug use. This study investigated relationships between illicit drug use and HIV status with depressive symptoms and HPG function in both men and women. Illicit drug use and HIV status were differentially associated with HPG function and depressive symptoms in men and women. Specifically, free testosterone concentrations were lower in men who use drugs and in women who are HIV positive. Estradiol concentrations were marginally lower in women, but not in men, who are HIV positive. Women and drug users reported the most depressive symptoms; however, impaired HPG function was associated with increased depressive symptoms in men only. Neither HPG function nor depression was impacted in an additive or synergistic manner by both drug use and HIV in either sex. These data indicate that illicit drug use is associated with altered HPG function in men and HIV infection is associated with altered HPG function in women. Furthermore, altered HPG function was associated with depressive symptoms in men, but not in women. Sex specific natural histories of illicit drug use and HIV infection, as they relate to endocrine and mental health, suggest a potential role for sex specific treatments to ameliorate these problems. The present data support recommendations of The National Academy of Science to consider gender differences in medical research. en
dc.format.extent 34528 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2006;16
dc.subject Hypothalamus en
dc.subject Gonads en
dc.subject Pituitary gland en
dc.title HPG function in men and women stratified by drug use and HIV status en
dc.type Presentation en


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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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