"Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal women"

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dc.contributor.author Wisniewski, Amy B.
dc.contributor.author Nguyen, Tam T.
dc.contributor.author Dobs, Adrian Sandra
dc.date.accessioned 2006-08-22T13:59:54Z
dc.date.available 2006-08-22T13:59:54Z
dc.date.issued 2002
dc.identifier.citation Hormone Research Volume 58, Issue 3, 2002, Pages 150-155 en
dc.identifier.issn 0301-0163
dc.identifier.uri http://hdl.handle.net/2092/401
dc.description Amy B. Wisniewski is an Assistant Professor of Biology at Drake University, Des Moines, Iowa. She can be contacted at amy.wisniewski@drake.edu en
dc.description.abstract Objectives: To investigate the cognitive effects of high-dose oral estrogen alone or in combination with oral methyltestosterone in postmenopausal women. Methods: Participants were tested with a randomized, double-blind design on the Identical Pictures, Cube Comparisons, Building Memory and Shape Memory tasks before and after 4 months of hormone treatment. Results: Women receiving estrogen and methyltestosterone maintained a steady level of performance on the Building Memory task, whereas those receiving estrogen alone showed a decrease in performance. Conclusions: These results indicate that the addition of testosterone to high-dose estrogen replacement exerts a protective effect on memory performance in postmenopausal women. Copyright © 2002 S. Karger AG, Basel. en
dc.description.sponsorship Portions of this manuscript were presented at the 1999 Endocrine Society Meeting, San Diego, Calif., USA and the 1999 North American Menopause Society Meeting, New York, N.Y., USA This research was partially supported by the Johns Hopkins University School of Medicine General Clinical Research Center, NIH/NCRR grant M01 RR00052. This research was also funded in part by Solvay Pharmaceuticals, Inc., Marietta, Ga., USA. en
dc.format.extent 89668 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.publisher S Karger AG (Basel, Switzerland) en
dc.subject Cognition. en
dc.subject Memory. en
dc.subject Menopause. en
dc.subject Perception. en
dc.subject Hormones, Sex. en
dc.title "Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal women" en
dc.type Article en


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