"Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal women"
Wisniewski, Amy B.
Nguyen, Tam T.
Dobs, Adrian Sandra
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Objectives: To investigate the cognitive effects of high-dose oral estrogen alone or in combination with oral methyltestosterone in postmenopausal women. Methods: Participants were tested with a randomized, double-blind design on the Identical Pictures, Cube Comparisons, Building Memory and Shape Memory tasks before and after 4 months of hormone treatment. Results: Women receiving estrogen and methyltestosterone maintained a steady level of performance on the Building Memory task, whereas those receiving estrogen alone showed a decrease in performance. Conclusions: These results indicate that the addition of testosterone to high-dose estrogen replacement exerts a protective effect on memory performance in postmenopausal women. Copyright © 2002 S. Karger AG, Basel.
Amy B. Wisniewski is an Assistant Professor of Biology at Drake University, Des Moines, Iowa. She can be contacted at firstname.lastname@example.org