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dc.contributor.authorDunbar, Robert L.
dc.date.accessioned2006-05-04T14:00:22Z
dc.date.available2006-05-04T14:00:22Z
dc.date.issued1995-06
dc.identifier.other1995 .D911
dc.identifier.urihttp://hdl.handle.net/2092/358
dc.descriptionv, 42 leaves. Advisor: Rodney Rogers.en
dc.description.abstractMDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was injected (i.p.) into male rats. Behavioral activity was determined for 24 hours on day 5 or day 12 following the beginning of the injections. A general increase in activity on day 5 was noted for the MDMA group (consistent with a release of 5-HT and/or catecholamines) while the activity of the MDMA/GM 1 group was lower, at the level of the control. At day 12 the MDMA group's activity was decreased relative to the control (consistent with a 5-HT depletion) while the MDWGM 1 group's activity was at or above that of the control. Biochemical analysis of brain tissue obtained from the animals sacrificed on day 7 or 14 following the beginning of the injections demonstrated a profound depletion of 5-HT, dopamine and norepinephrine with administration of MDMA. The MDMA/GMl group also showed this depletion, though to a smaller degree, suggesting some attenuation of toxic effects.en
dc.format.extent11396590 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherDrake Universityen
dc.relation.ispartofseriesDrake University Theses, College of Arts and Sciences;1995
dc.subjectEcstasy (Drug)en
dc.subjectDrugs--Side effectsen
dc.subjectNeuropharmacolgyen
dc.subjectToxicological interactionsen
dc.subjectGangliosides--Phyiological effecten
dc.titleEffects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brainen
dc.typeThesisen


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