Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain
Dunbar, Robert L.
MetadataShow full item record
MDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance the rate of recovery of the neurons from the MDMA-induced effects. To assess this GM1 effect, MDMA (20 mglkg x 4 days), GM1 (40 mgkg), MDMA and GM1 or saline was injected (i.p.) into male rats. Behavioral activity was determined for 24 hours on day 5 or day 12 following the beginning of the injections. A general increase in activity on day 5 was noted for the MDMA group (consistent with a release of 5-HT and/or catecholamines) while the activity of the MDMA/GM 1 group was lower, at the level of the control. At day 12 the MDMA group's activity was decreased relative to the control (consistent with a 5-HT depletion) while the MDWGM 1 group's activity was at or above that of the control. Biochemical analysis of brain tissue obtained from the animals sacrificed on day 7 or 14 following the beginning of the injections demonstrated a profound depletion of 5-HT, dopamine and norepinephrine with administration of MDMA. The MDMA/GMl group also showed this depletion, though to a smaller degree, suggesting some attenuation of toxic effects.
Showing items related by title, author, creator and subject.
Effects of Audio Cueing on Teacher Praise and Subsequent Effects on Children's Rule Violations in a Day Care Berty, Peter Tamas (Drake University, 1977-06)The problems. The experimental problems were to demonstrate the effectiveness of an audio cueing procedure in manipulating teacher praise and to assess any subsequent changes in students' violations of classroom rules in ...
Norman, Andrew T.; Russell, Cristel Antonia (Hebrew University of Jerusalem, School of Business Administration, 2006-07)Email petitions to complete online surveys may be forwarded beyond the intended sample. We term this phenomenon the pass-along effect and investigate it as a factor that can influence the nature and size of survey samples ...