"Detection of PIGF protein in neonatal rat cardiomyocytes"

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dc.contributor.author Schweizer, Marin
dc.contributor.author Bohman, Kyle
dc.contributor.author Mittelstedter, Carrie
dc.contributor.author Colton, Benjamin
dc.contributor.author Torry, Ronald J.
dc.contributor.author Torry, Donald S.
dc.date.accessioned 2005-07-05T14:00:44Z
dc.date.available 2005-07-05T14:00:44Z
dc.date.issued 2005-07-05T14:00:44Z
dc.identifier.uri http://hdl.handle.net/2092/277
dc.description Marin Schweizer, Kyle Bohman, Carrie Mittelstedter and Ben Colton are all Drake University students. Ronald J. Torry is Associate Professor of Pharmacology at Drake University. Donald S. Torry is on the faculty at Southern Illinois University School of Medicine. en
dc.description.abstract Angiogenesis, the formation of blood vessels, can provide blood to the heart when its normal arteries are compromised. Angiogenesis is highly dependent on the Vascular Endothelial Growth Factor (VEGF) family. Placental Growth Factor (PlGF) is a member of this family and is crucial for pathological angiogenesis in the adult. PlGF coupled with the more common VEGF could greatly increase angiogenesis in the heart tissue, thus providing oxygen to ischemic heart tissue. Previous research has shown that PlGF mRNA increases with six hours of hypoxia which models ischemia. However, not much is known about PlGF expression on the protein level. We intend to establish that PlGF protein expression will increase in rat cardiomyocytes which have undergone 6, 12 and 24 hours of hypoxia compared to normoxic rat cardiomyocytes. This information will later be used in studies of potential protective treatments using PlGF. en
dc.description.sponsorship Drake University, College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences. en
dc.format.extent 839059 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2005;15
dc.subject Angiogenesis en
dc.subject Placenta Growth Factor (PIGF) en
dc.subject Vascular Endothelial Growth Factor (VEGF) en
dc.subject Ischemic heart disease en
dc.title "Detection of PIGF protein in neonatal rat cardiomyocytes" en
dc.type Presentation en

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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