"Indole derivatives interact with DOPC in Langmuir monolayers"

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dc.contributor.author Brozik, Melissa
dc.contributor.author Frazee, Erin
dc.contributor.author Bohorquez, Maria
dc.date.accessioned 2005-06-28T19:03:07Z
dc.date.available 2005-06-28T19:03:07Z
dc.date.issued 2005-06-28T19:03:07Z
dc.identifier.uri http://hdl.handle.net/2092/275
dc.description Melissa Brozik and Erin Frazee are students at Drake University. Maria Bohorquez is Associate Professor of Chemistry in the College of Arts and Sciences at Drake. She can be contacted at maria.bohorquez@drake.edu en
dc.description.abstract Molecular interactions between indole derivatives and 1,2-di-oleoyl-sn-glycero-3-phosphocholine (DOPC) were studied using a Nima Langmuir-Blodgett (LB) trough. A 0.25 M phosphate buffer sub-phase was used with a physiological pH range of 7.31-7.48. The air-phosphate buffer interface was examined at room temperature. Constant ionic strength was maintained by 0.100 M potassium chloride (KCl). Two different indole derivatives were used, indole and tryptophan, in concentrations of 3.0 uM and 5.0 uM. It is evident when examining the isotherms that the DOPC monolayer is expanded in the presence of indole derivatives, as the area per molecule was increased by 0.02nm2/molecule. en
dc.description.sponsorship Drake University, College of Arts and Sciences, Department of Chemistry, and NSF Grant 0311325. en
dc.format.extent 852888 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2005;18
dc.subject Fluorescence en
dc.subject Monolayers en
dc.subject Phospholipids en
dc.subject Amino acids en
dc.title "Indole derivatives interact with DOPC in Langmuir monolayers" en
dc.type Presentation en

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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