"Therapeutic efficacy of herbal extracts for cancer chemotherapy"

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dc.contributor.author Strenk, Meghan
dc.contributor.author Fuller, Lisa
dc.contributor.author Iannone, Alex
dc.contributor.author Taylor, Holland
dc.contributor.author Mortenson, Luke, Ph.D.
dc.contributor.author Brown, Keri
dc.contributor.author Clark, David
dc.contributor.author Strom, David, Ph.D.
dc.contributor.author Henry, Matt, Ph.D.
dc.contributor.author Nelson, Brandon
dc.date.accessioned 2005-06-10T16:40:26Z
dc.date.available 2005-06-10T16:40:26Z
dc.date.issued 2005-06-10T16:40:26Z
dc.identifier.uri http://hdl.handle.net/2092/263
dc.description Megan Strenk graduated from Drake in May 2005, with a B.S. in Biochemistry, Cell and Molecular Biology. Lisa Fuller is currently a Pharmacy student at Drake. en
dc.description.abstract In recent years, complementary and alternative medicine (CAM) has become more widespread in the treatment of a variety of illnesses. Several of these alternative herbal therapies claim that they are effective in fighting cancer, though these claims have yet to be supported by the FDA. It is our goal to develop an assay that can evaluate the efficacy of some of these herbal treatments against cancer. Thus far, our main focus has been on the compound hydroxycinnamoaldehyde (HCA), which is the active ingredient in the herb Rou Gui. We have looked at the efficacy of this drug using two methods. The first, flow cytometry, uses DNA to determine cell death. The second, a caspase-3 assay, surveys for a protein present in early apoptosis. These two assays have allowed us to find a dose-response curvefor 32D cells using two traditional concer treatments (Taxol and Doxorubicin), each with and withoutthe addition of HCA. The difference in the curves for each drug with and without HCA will tell us whether or not the herbal has an effect for that treatment. en
dc.description.sponsorship Drake University, College of Arts and Sciences, Department of Biochemistry, Cell and Molecular Biology, and the College of Pharmacy. Des Moines University, Department of Physiology and Pharmacology. en
dc.format.extent 988808 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.relation.ispartofseries DUCURS 2005;24
dc.subject Cancer--Alternative treatment en
dc.subject Alternative medicince en
dc.subject Herbs--Therapeutic use en
dc.subject Phytotherapy en
dc.title "Therapeutic efficacy of herbal extracts for cancer chemotherapy" en
dc.title.alternative "2' hydroxycinnamaldehyde exhibits potential as an anticancer chemotherapeutic agent" en
dc.type Presentation en

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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