"Effects of Salts on the Clouding and Micellization Behavior of Pluronic F127 (registered trademark) Solutions"
Pandit, Nivedita K.
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SubjectMicelles; Cloud point; Critical micellization temperature; Critical micellization concentration; Non-ionic surfactant; Pluronic F127; Poloxamer; Surface active agents; Pharmaceutical sciences
We have investigated the effect of NaCl, Na2SO4, Na3PO4 and NaSCN on the cloud point (CP), and critical micellization temperature (cmt) of F127 solutions. Salts have been shown to alter micellization of other non-ionic surfactants, and the gel transition temperatures of F127. Such changes are important to consider in formulation systems with F127.
This was presented as a poster session at the Annual Meeting of the American Association of Pharmaceutical Scientists in 2001.