Now showing items 1-8 of 8

  • Analysis of mRNA changes as a function of learning and methamphetamine exposure 

    Kostelc, Kate; Sleister, Heidi; Klipec, William D. (2007-05-31)
    Methamphetamine is a powerful, addictive drug that is of great concern in Iowa and the Midwest. Powerful methamphetamine abuse is correlated with depression and learning disabilities (e.g. attention deficit disorder). ...
  • Complementary approaches to identify genes important for chromosome segregation 

    Bjorge, Ashley; Bryant, Andy; Lauer, Stephen; Levesque, Erin; Madsen, Rebecca; Meyer, Katy A.; Rimbey, Guy; Starkweather, Ashley; Verdick, Christopher; Watson, Bryan; Sleister, Heidi (2007-05-17)
    Faithful transmission of chromosomes during cell division is essential to the functioning of the eukaryotic cell. In humans, errors during chromosome segregation are correlated with diseases such as Down Syndrome and cancer. ...
  • "Genetic analysis of the human disease-causing gene ATM in yeast Tel1 and Mec1 mutants" 

    Renze, Anne; Sleister, Heidi (2006-06-07)
    Ataxia-telangiectasia (A-T) is a recessive human disorder characterized by hypersensitivity to radiation, elevated risk of cancer development, nervous degeneration, premature senescence, and immune deficiencies. A-T is ...
  • "Identification of yeast genes important for chromosome transmission" 

    Leeson, Stephanie; Fatland, Sarah; Bellani, Denisa; Scolaro, Eric; Wood, Abby; Young, Chris; Sleister, Heidi (2006-05-05)
    Accurate transmission of chromosomes during cell division requires that chromosomes are fully replicated and free of damage prior to cell division. Furthermore, cellular processes that separate chromosomes must be functional. ...
  • "Implementation of a genetic screen to elucidate proteins important for chromosome transmission" 

    Bjordahl, Ryan; Davison, Rob; Hatz, Daniel; Kostelc, Kate; Larew, Robbie; Miller, Adam; Rusdianto, Eveline; Sawaya, Elizabeth; Sleister, Heidi (2006-06-07)
    The process of cell division is highly regulated in eukaryotic cells. Failure to transmit chromosomes accurately during cell division can result in cell death or abnormal growth (e.g., tumors). Proteins that associate in ...
  • Inhibition of drug efflux by pluronics in S. cerevisiae 

    Diezi, Thomas; Ruggle, Brian; Pandit, Nivedita K.; Sleister, Heidi (2007-05-31)
    Overexpression of P-gp efflux pumps is believed to be responsible for multidrug resistance of mammalian cancer cells. Inhibition of these pumps is expected to increase the efficacy and decrease the toxicity of chemotherapeutic ...
  • Isolation of yeast genes that suppress the chromosome loss defect of 'YAC stability in mitosis' mutants. 

    Ruggle, Brian; Rusdianto, Eveline; Sleister, Heidi (2007-05-17)
    The eukaryotic cell cycle and processes that maintain genome stability occur with high fidelity. Mutations in genes important for the structure, replication, repair, and/or segregation of chromosomes are correlated with ...
  • "Protection of the yeast Saccharomyces cerevisiae from UV-C light" 

    Adams, Mehan; Kong, Kai Ling; Martis, Lydia; McManus, Karen; Pillischafske, Paige; Walleser, Nathan; Weisensel, Ashley; Voegele, Barbara; Zorich, Kristen; Mulville, Kali; Roby, Tiffany; Swafford, Eric; Uhlman, Doug; Walkup, Kristina; Sleister, Heidi (2006-06-07)
    Excessive exposure to sunlight can be harmful as the sun's ultraviolet (UV) rays cause DNA damage. If this damage is not repaired in human cells, cancer and/or cell death can result. With the incidence of skin cancer growing ...