Systematic Review: Impaired Drug Absorption in Patients with Ostomy or Shortened Bowel

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Show simple item record Ferring, Atalie Snodgrass, Lindsay 2011-04-25T15:34:43Z 2011-04-25T15:34:43Z 2011-04-25T15:34:43Z
dc.description Mentor: Dr. Nita Pandit en_US
dc.description.abstract Drug absorption may be a problem in patients with ostomies and shortened bowel. Malabsorption of certain drugs and drug products is possible due to the reduction in intestinal surface area as a result of surgical resection. Clinicians are often unaware of this problem when creating dosing regimens and there is insufficient literature on this topic. To systematically review published evidence of impaired drug absorption in patients with ostomy or shortened bowel. To make recommendations to clinicians for appropriate drug therapy in these patients. Studies were obtained through systematic literature searches of MEDLINE, SCOPUS, SciFinder Scholar, and SuperSearch databases (1983- 2010) for English articles with keywords: drug malabsorption, absorption, bioavailability, ostomy, ileostomy, short bowel, and drug monitoring. Two reviewers independently assessed studies for inclusion. Ten studies were identified investigating impaired absorption in patients with ostomies or shortened bowel. Evidence for diminished drug absorption was found in 3/10 studies examining ostomies and 7/10 studies involving shortened bowel, including problems with sixty-five drug products. Drug malabsorption appears to be more well-known in patients with shortened bowel over patients with ostomies. More studies are needed to evaluate the effect of potential drug malabsorption in patients with ostomies. Approaches to further research will be presented. Reduced drug absorption is very likely in patients with ostomies or shortened bowel, especially for sustained-release or extended-release products, and for poorly absorbed drugs. Individual dose-adjustment, selection of a different route of administration, and therapeutic monitoring of blood levels by clinicians may also be required. en_US
dc.description.sponsorship Drake University, College of Pharmacy & Health Sciences en_US
dc.language.iso en_US en_US
dc.relation.ispartofseries DUCURS 2011;9
dc.subject Ostomates--Drug testing en_US
dc.subject Drugs--Absorption and adsorption en_US
dc.subject Drug monitoring en_US
dc.subject Enterostomy en_US
dc.title Systematic Review: Impaired Drug Absorption in Patients with Ostomy or Shortened Bowel en_US
dc.type Presentation en_US

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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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