Analysis Of Candidate Genes That Suppress Chromosome Loss In Saccharomyces Cerevisiae Mutants With Defects In Chromosome Transmission

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dc.contributor.author Adjei, Naomi
dc.contributor.author Ellis, Alyssa
dc.contributor.author Feigenbutz, Lanie
dc.contributor.author Gwinn, Traci
dc.contributor.author Kolnik, Jim
dc.contributor.author Miller, Lindsey
dc.contributor.author Patel, Neel
dc.contributor.author Peterson, Kevin
dc.contributor.author Richardson, Alex
dc.contributor.author Setsodi, Christine
dc.contributor.author Michaels, Whitney
dc.date.accessioned 2011-04-15T18:49:46Z
dc.date.available 2011-04-15T18:49:46Z
dc.date.issued 2011-04-15T18:49:46Z
dc.identifier.uri http://hdl.handle.net/2092/1547
dc.description Mentor: Heidi Sleister en_US
dc.description.abstract Errors in the eukaryotic cell cycle and processes that maintain genome stability can result in abnormal chromosome number and structure (e.g., in humans- Down Syndrome, cancer). The common baker’s yeast S. cerevisiae is a great model system for the analysis of chromosome transmission as yeast artificial chromosomes (YACs) can be lost or rearranged without harming the cell. In an effort to identify proteins important for chromosome transmission, yeast mutants that display increased loss of a YAC during cell division were generated. Suppressor analysis resulted in the isolation of both single and high copy yeast genomic plasmids that improve the chromosome loss defect in these mutants. Subsequent analysis revealed multiple candidate genes present within the suppressor plasmids. Each gene is being individually cloned and assayed for suppression of chromosome loss. en_US
dc.description.sponsorship Drake University, College of Arts & Sciences, Department of Biology en_US
dc.language.iso en_US en_US
dc.relation.ispartofseries DUCURS 2011;2
dc.subject Saccharomyces cerevisiae en_US
dc.subject Chromosomes en_US
dc.subject Genes--Analysis en_US
dc.title Analysis Of Candidate Genes That Suppress Chromosome Loss In Saccharomyces Cerevisiae Mutants With Defects In Chromosome Transmission en_US
dc.type Presentation en_US


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  • DUCURS [196]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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