Abstract:
Malaria is a mosquito –borne infectious disease of humans caused by the bite of a female anopheles
mosquito. The disease is prevalent in tropical regions of the world mainly in sub-Saharan Africa, Asia
and Latin America. Anti-malarial medications such as chloroquine, artemisinin, doxycycline,
Metakelfin and other drugs are used to treat malarial infections. In this experiment the antimalarial
drug, Metakelfin was analyzed to identify the presence of the main active ingredients. The extraction
of such ingredients was using the appropriate solvents and gave a mixture of two components:
Pyrimethamine and sulfamethoxyprazine which were further separated using the column chromatography.
Characterization of such compounds involved the use of melting point determinations as well
as infrared spectroscopy and gas chromatographic techniques.
