Inhibitory Effects of Ketoconazole on the Oxidation of Linoleic Acid Micelles, Phospholipid Liposomes, and Human Low Density Lipoprotein (h-LDL)

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dc.contributor.author Munroe, Melissa E.
dc.date.accessioned 2010-09-15T15:13:01Z
dc.date.available 2010-09-15T15:13:01Z
dc.date.issued 1993-07
dc.identifier.other 1993 .M926
dc.identifier.uri http://hdl.handle.net/2092/1424
dc.description 36 leaves en_US
dc.description.abstract Soybean lipoxygenase (SLO) (500-5000 units/ml), Fe(III)Cl3/ascorbate (5-100microM) and hematin (5-100microM) induced oxidative modification of lipids present in micelles of linoleic acid (0.5 mM), liposomes prepared from phospholipid extracts of bovine brain (2.5 mg/ml), and h-LDL (0.5 mg/ml). Oxidation of the lipid substrates was determined by the formation of thiobarbituric acid reactive substances and conjugated dienes. Free iron (Fe(III)Cl3/ascorbate) was the strongest initiator, followed by hematin and SLO. Ketoconazole (KC) attenuated lipid oxidation in a concentration dependent manner at pharmacologically relevant levels (25-100microM) in all three substrates. Pretreatment of liposomes and h-LDL with KC produced greater attenuation of lipid oxidation by the various initiators in comparison to free KC. en_US
dc.language.iso en_US en_US
dc.publisher Drake University en_US
dc.relation.ispartofseries Drake University, College of Arts and Sciences;1993
dc.subject Ketoconazole en_US
dc.subject Low density lipoproteins en_US
dc.subject Micelles en_US
dc.subject Liposomes en_US
dc.title Inhibitory Effects of Ketoconazole on the Oxidation of Linoleic Acid Micelles, Phospholipid Liposomes, and Human Low Density Lipoprotein (h-LDL) en_US
dc.type Thesis en_US


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