Show simple item record

dc.contributor.authorMunroe, Melissa E.
dc.date.accessioned2010-09-15T15:13:01Z
dc.date.available2010-09-15T15:13:01Z
dc.date.issued1993-07
dc.identifier.other1993 .M926
dc.identifier.urihttp://hdl.handle.net/2092/1424
dc.description36 leavesen_US
dc.description.abstractSoybean lipoxygenase (SLO) (500-5000 units/ml), Fe(III)Cl3/ascorbate (5-100microM) and hematin (5-100microM) induced oxidative modification of lipids present in micelles of linoleic acid (0.5 mM), liposomes prepared from phospholipid extracts of bovine brain (2.5 mg/ml), and h-LDL (0.5 mg/ml). Oxidation of the lipid substrates was determined by the formation of thiobarbituric acid reactive substances and conjugated dienes. Free iron (Fe(III)Cl3/ascorbate) was the strongest initiator, followed by hematin and SLO. Ketoconazole (KC) attenuated lipid oxidation in a concentration dependent manner at pharmacologically relevant levels (25-100microM) in all three substrates. Pretreatment of liposomes and h-LDL with KC produced greater attenuation of lipid oxidation by the various initiators in comparison to free KC.en_US
dc.language.isoen_USen_US
dc.publisherDrake Universityen_US
dc.relation.ispartofseriesDrake University, College of Arts and Sciences;1993
dc.subjectKetoconazoleen_US
dc.subjectLow density lipoproteinsen_US
dc.subjectMicellesen_US
dc.subjectLiposomesen_US
dc.titleInhibitory Effects of Ketoconazole on the Oxidation of Linoleic Acid Micelles, Phospholipid Liposomes, and Human Low Density Lipoprotein (h-LDL)en_US
dc.typeThesisen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record