Stability of Levothyroxine in Aliquots and Capsules Prepared by Extemporaneous Compounding

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Show simple item record Salton, Jason 2010-05-10T14:47:03Z 2010-05-10T14:47:03Z 2010-05-10T14:47:03Z
dc.description Advisor: Deepa A. Rao en_US
dc.description.abstract Levothyroxine (T4) is commonly used to supplement low levels of endogenous thyroid hormones in patients with thyroid hormone deficiency. Dosing of T4 is highly individualized and therefore is often compounded extemporaneously by pharmacists. Extemporaneous preparation of T4 involves preparing a ready to use aliquot of T4 in an inert excipient which is then used to prepare the capsules dispensed to the patients. Aliquots and capsules of T4 were assessed for content over a four month span to determine an appropriate beyond use dating for capsules prepared by a local compounding pharmacy, Central Iowa Compounding (CIC). CIC provided a 1:100 T4 aliquot and 95 μg T4 capsules for the study. Stability of T4 was assessed by high pressure liquid chromatography (HPLC) developed to detect T4 and its solid state oxidized degradation product using UV detection. Stability was assessed on days 1, 7, 14, 21, 30, 45, 60, 90, and 120. As of day 120 of the stability study, the average content of T4 in the aliquot was 87.09% ± 4.04 of the original concentration. The 95 mcg T4 capsule retained full activity (100%) over the four month period. Based on the results thus far T4 content in aliquot is statistically significantly lower for day 120 only while capsule content of T4 is maintained over 120 days. en_US
dc.description.sponsorship Drake University, Department of Pharmaceutical, Biomedical & Administrative Sciences en_US
dc.language.iso en_US en_US
dc.relation.ispartofseries DUCURS 2010;15
dc.subject Drug stability en_US
dc.subject Capsules (Pharmacy) en_US
dc.subject Drugs--Dosage forms en_US
dc.subject Thyroid hormones en_US
dc.subject Hypothyroidism--Drug use en_US
dc.title Stability of Levothyroxine in Aliquots and Capsules Prepared by Extemporaneous Compounding en_US
dc.type Presentation en_US

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  • DUCURS [193]
    Poster sessions and presentation from the Drake University Conference on Undergraduate Research in the Sciences held each April at Olmsted Center on the Drake campus.

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