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dc.contributor.authorPieper, William John
dc.date.accessioned2010-02-18T14:49:15Z
dc.date.available2010-02-18T14:49:15Z
dc.date.issued1973-09
dc.identifier.other1973 .P598
dc.identifier.urihttp://hdl.handle.net/2092/1094
dc.description38 leaves.en_US
dc.description.abstractThe problem. Eighty-seven patients clinically diagnosed as having Down's syndrome were studied by chromosome analysis at Woodward State Hospital, Woodward, Iowa, during June and July of 1972. Procedure. A cytogenetic analysis was made on chromosomes prepared from leucocytes cultured from peripheral blood. Ten cells were counted and karyotypes prepared for each patient. Findings. Among the eighty-seven patients, 54 males and 33 females, 60 (69%) were trisomic, 26 (29.9%) showed possible mosaicism and 1 (1.15%) carried a translocation. Three of the residents, including the patient with a translocation, were one of a set of twins. Conclusion. The frequency of Down's syndrome based on a Woodward population of 750 residents was 11.6%. This frequency is in agreement with a reported frequency of 11.2% individuals with Down's syndrome determined from a 1967 census of 23,211 people in institutions for the mentally retarded. The frequency of 60 trisomic Down syndrome patients (69%) was lower than the 93% figure found by most investigators. The observed frequency (1.15%) of translocation Down's syndrome is lower than reported frequencies of 3 to 4% for other institutions. A frequency of mosaic Down's syndrome in the Woodward population of 29.9% is considerably higher than the 1 to 2% reported elsewhere for similar populations. The observed cases of presumptive mosaicism may include cases of regular trisomy which wiil be resolved by more extensive cytogenetic analysis. Recommendations. A follow-up study to more completely characterize the mosaic Down's syndrome population is warranted to resolve the large observed deviation.en_US
dc.language.isoenen_US
dc.publisherDrake Universityen_US
dc.relation.ispartofseriesDrake University, School of Graduate Studies;1973
dc.subjectDown Syndromeen_US
dc.subjectPeople with mental disabilities--Iowa--Woodwarden_US
dc.subjectCytogeneticsen_US
dc.titleA Cytogenetic and Karyotypic Study of Eighty-Seven Patients Clinically Diagnosed as Having Down's Syndrome at Woodward State Hospitalen_US
dc.typeThesisen_US


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